Some Advertisements that claim they have real HGH in a spray or pill may in fact contain small amounts of HGH. There is some evidence that HGH can enter the blood stream if absorbed directly into the membranes of the mouth, but oral HGH therapy is not as effective as a medically supervised injectable program. It has been medically proven that HGH cannot be absorbed through the digestive system.
hormone injectable can be given either subcutaneously or by intra-muscular
injection with equal therapeutic activity.
Subcutaneous administration is now used almost exclusively because
intra-muscular administration is fraught with an increase in side
effects without any additional therapeutic benefit. Back in Dr.
Rudman's time, growth hormone was typically dosed three times
a week in what we now consider a high dose regimen. People would
typically receive 12-18 units per week given in injections of
4-6 units, three times a week.
Although great benefits were seen, side effects were very common,
and much more bothersome than those we see today.
Currently we use only about half the weekly dose used in Dr. Rudman's
study, by smaller and more frequent injections, which provide
both a better clinical response and far fewer side-effects.
In one study on growth hormone deficient children, those that
received daily injections increased their height during the study
period by 9.7 centimeters more than those who received thrice-weekly
injections. Besides the low dose-high frequency technique, the
physicians at Cenegenics® also employ morning injections as opposed
to evening. The reason for this has to do with the biofeedback
mechanism for growth hormone. Most of our natural pituitary growth
hormone secretion occurs at night during deep stages of sleep.
Injecting growth hormone at night raises the serum level of growth
hormone precisely during the time the pituitary is scheduled to
This high serum level of growth hormone from the injection can
suppress our natural pituitary function by negative feedback.
We then not only lose the benefit of our own endogenous growth
hormone, but also run the risk of surpressing the pituitary, thus
making it "lazy". For the most part, the pituitary has completed
its function and is at rest by 5 a.m.
Therefore injecting after awakening in the morning results in
injecting "on top of the peak" of endogenous (our own) growth
hormone, so as not to suppress the pituitary. By the time the
pituitary is ready again for its nighttime activity, the growth
hormone given in the morning injection has been completely metabolized.
This eliminates the risk of pituitary suppression.